AP4 is frequently expressed in primary CRCs. However, the in vivo relevance of AP4 for development of intestinal tumor formation has not been analyzed by genetic approaches. ApcMin/+ mice with deletion of AP4 were generated and analyzed. The mRNA expression profiles of intestinal adenomas with and without functional AP4 were compared. SOURCE: Markus Kaller (markus.kaller@med.uni-muenchen.de) - Experimental and Molecular Pathology Ludwig-Maximilians-University Munich

Pluto Bioinformatics

GSE99434: AP4 regulates stem and Paneth cell homeostasis and promotes adenoma initiation in the intestine (small intestinal organoid)