Pluto Bioinformatics

GSE76874: Expression profiling of murine cytogenetic normal p53-/- shPU.1 AML cells following gradual PU.1 restoration

Bulk RNA sequencing

We have utilized advanced RNAi technology to dynamically restore endogenous PU.1 expression in p53-deficient AML cells . This causes rapid cell cycle shutdown and myeloid differentiation. PU.1 restoration results in regression and clearance and prolongs survival. SOURCE: Ruijie Liu (cliu@wehi.edu.au) - Ritchie lab walter and eliza hall institute of medical research