Cranial irradiation (IR), an effective tool to treat malignant brain tumors, triggers a chronic pro-inflammatory microglial response, at least in the adult brain. Using bulk RNA sequencing, we show that the microglial response in the juvenile mouse hippocampus is rapid, but returns toward normal within 1 week. The sensome of irradiated hippocampal microglia reveals an immediate response that declines after one day.  Irradiation of the juvenile brain induces a highly ordered temporal progression of the inflammatory and phenotypic microglial genes SOURCE: Ahmed Osman (ahmed.osman@ki.se) -  Karolinska Institute

Pluto Bioinformatics

GSE149522: The transcriptomic profile of the hippocampal microglia in the irradiated juvenile mouse brain