Pluto Bioinformatics

GSE53258: The role of TFEB in retinoid induced differentiation of NB4 APL leukemic cells (shTFEB)

Bulk RNA sequencing

We report the use of RNAseq to determine the role of the TFEB transcription factor in all-trans retinoic acid induced differentiation of NB4 acute promyelocytic leukemia (APL) cells. We used lentiviral mediated shRNA approaches to functionally deplete TFEB in NB4 cells and compared the transcriptomes of wild type, scramble control shRNA and shTFEB knockdown cells treated with ethanol (control) versus all-trans retinoic acid for 72 hours. SOURCE: Nigel,P,Mongan University of Nottingham

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