Pluto Bioinformatics

GSE157109: Gene expression profiling data following TRIM8 knockdown in MCF-7 cells

Bulk RNA sequencing

Breast cancer (BC) is the most common female malignancies worldwide, and 70% of cases are estrogen receptor (ER) positive. In this study, we report that the E3 ubiquitin ligase TRIM8 acts as a novel regulator of ER signaling. TRIM8 is downregulated in BC and is associated with poor prognosis. In addition, the protein level of TRIM8 is negatively correlated with ER expression. To investigate whether TRIM8 mediated estrogen signaling pathway, we generated a knockdown model of TRIM8 in human MCF7 cells. SOURCE: Weixiang He (heweixiang@whu.edu.cn) - Wuhan University

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