Pluto Bioinformatics

GSE96738: Transcriptional profile of homozygous inactivation of Nf1 in mature oligodendrocytes

Bulk RNA sequencing

White matter abnormalities have been observed in Neurofiromatosis type 1 (NF1) patients and in mouse models of the disease, and disturbed myelin has been proposed to cause of neurological issues in NF1 patients. Analysis of the transcriptional changes following inactivation of Nf1 in mature oligodendrocytes, the cell type producing myelin, can give information on the molecular pathways affected in NF1.; Homozygous inactivation of Nf1 was induced by Tamoxifen treatment of adult PlpCreER;Nf1flox/flox mice, 1 month later, RNA from the optic nerve was isolated and sequenced SOURCE: Kwangmin Choi Cincinnati Children's Hospital Medical Center