Pluto Bioinformatics

GSE71862: Differential Gene Expression between MCF10A and MCF7 cells

Bulk RNA sequencing

These RNA-seq data were generated to correlate with genomic interaction data in a related Hi-C analysis. MCF10A is a normal-like mammary epithelial cell line and MCF7 is a transformed estrogen responsive breast cancer cell line derived from a metastatic site; both are commonly used in models of breast cancer progression. Analysis revealed a set of genes related to repression of WNT signalling that were both up-regulated in MCF7 and located in genomic regions that had transitioned from closed to open structure in MCF7. SOURCE: Jane Lian ( - Jane B Lian & Gary S Stein University of Vermont College of Medicine

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