Pluto Bioinformatics

GSE138272: FOXP3 protects conventional human T cells from premature restimulation-induced cell death

Bulk RNA sequencing

Transcriptome profiling and functional analyses on expanding Tcons revealed that FOXP3 enhances expression of the SLAM family receptor CD48, which in turn sustains basal autophagy and suppresses pro-apoptotic p53 signaling. Our findings suggest that FOXP3 governs a distinct transcriptional program in early-stage effector Tcons that maintains RICD resistance via CD48-dependent protective autophagy and p53 suppression. SOURCE: Clifton,Lee,Dalgard (cdalgard@usuhs.edu) - Dalgard Uniformed Services University