Natural killer (NK) cells are innate lymphocytes that possess features of adaptive immunity, such as the ability to recognize specific antigen, among others. In MCMV infection, the engagement of a subset of NK cells expressing an activating receptor Ly49H with MCMV-derived glycoprotein m157 results in a clonal-like expansion and the generation of a small pool of long-lived memory cells with higher Ly49H expression than the naive Ly49H-expressing NK cell pool. In this study, we interrogate the transcriptional differences between NK cells that express high verus low levels of Ly49H early after infection. SOURCE: Endi,K,Santosa (santosae@mskcc.org) -  Memorial Sloan Kettering Cancer Center

Pluto Bioinformatics

GSE129490: Avidity Selection of Natural Killer Response to MCMV