Pluto Bioinformatics

GSE145147: A role of the CTCF binding site at enhancer Ea in Tcra rearrangement

Bulk RNA sequencing

We found that the CTCF binding site (named as EACBE) at the enhancer E of Tcra is essential for normal Tcra rearrangement.The EACBE deletion impaired the TAD structure of the 3 region of the Tcra/d locus and the interactions between the proximal V genes and the J genes without changing the accessibility of the J array. SOURCE: Hao bingtao (haobingtao@gmail.com) - Southern Medical University