Pluto Bioinformatics

GSE145147: A role of the CTCF binding site at enhancer Ea in Tcra rearrangement

Bulk RNA sequencing

We found that the CTCF binding site (named as EACBE) at the enhancer E of Tcra is essential for normal Tcra rearrangement.The EACBE deletion impaired the TAD structure of the 3 region of the Tcra/d locus and the interactions between the proximal V genes and the J genes without changing the accessibility of the J array. SOURCE: Hao bingtao ( - Southern Medical University

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