By utilizing single-cell analysis at different times after P2 injury(0, 3, and 5 dpi), we discovered that neonatal microglia undergo a transient activation and play at least two critical roles in scar-free healing. First, they transiently secrete fibronectin and its binding proteins, to form extracellular matrix bridges that ligate the severed ends. Second, neonatal, but not adult, microglia express a number of extracellular and intracellular peptidase inhibitors, along with other molecules involved in inflammatory resolution. SOURCE: Riki Kawaguchi (rkawaguchi@mednet.ucla.edu) - Informatics Center for Neurogenetics and Neurogenomics (ICNN). University of California Los Angeles

Pluto Bioinformatics

GSE150871: Scar-free healing and axon regeneration after spinal cord injury in neonatal mice is orchestrated by microglia