Forkhead box a2 (FOXA2) is a transcription factor expressed specifically in the glands of the uterus and a critical regulator of uterine gland differentiation, development and function. Here, we tested the hypothesis that FOXA2-regulated genes in the uterine glands impact development of the decidua, placenta and fetus using a littermate study design. On gestational day (GD) 8.5, the anti-mesometrial and mesometrial RNA was sequenced bewteen wild-type and cKO mice. The anti-mesometrial and mesometrial decidua transcriptome was noticeably altered in FOXA2 cKO mice. SOURCE: Thomas Spencer (spencerte@missouri.edu) - ASRC 158 University of Missouri

Pluto Bioinformatics

GSE154026: Forkhead box a2 (FOXA2) impacts uterine decidualization and fetoplacental development