Pluto Bioinformatics

GSE46665: Identification of differentially expressed transcripts and pathways one week and six months following implant of left ventricular devices

Bulk RNA sequencing

A specific set of genes involved in regulating cellular immune response, antigen presentation, and T cell activation and survival were down-regulated 7 days after LVAD placement. 6 months following LVAD placement, the expression levels of these genes were significantly increased; yet importantly, remained significantly lower than age and sex-matched samples from healthy controls. SOURCE: Rod,A.,Staggs (stagg004@umn.edu) - Minnesota Informatics