Pluto Bioinformatics

GSE76647: The effect of Foxc1 deficiency on undifferentiated and differentiated human primary keratinocytes

Bulk RNA sequencing

In this study, we used a RNA-sequencing (RNA-seq) approach to analyze the whole transcriptomes of human primary Keratinocytes (KC) at undifferentiated stage and differentiated stage with and without FOXC1 knockdown. Each treatment condition have 2 or 3 replicates. 10 million reads were collected. A total of 8202 genes were designated as present (RPKM>5 in at least one sample). 635 genes were differentially expressed (FDR<0.01, P<0.000774201). FOXC1 knock-down significantly impaired keratinocytes differentiation process. SOURCE: Lianghua Bin (binl@njhealth.org) - National Jewish Health