Pluto Bioinformatics

GSE146899: Interaction with Cholangiocytes and Neutrophils

Bulk RNA sequencing

Alcoholic hepatitis (AH) is a life-threatening disease with limited treatment options. The presence of cholestasis worsens prognosis but the responsible mechanism is unknown. AH results in infiltration of polymorphonuclear neutrophils (PMNs) in the liver, and cholestasis often reflects bile duct pathology, so we investigated whether and how PMNs interact with cholangiocytes in AH. SOURCE: Michael Nathanson (masahiro99@med.uoeh-u.ac.jp) - Michael Nathanson Yale university