Pluto Bioinformatics

GSE142417: Interleukin-11 signaling drives vascular smooth muscle phenotypic switching and contributes to aortic remodelling

Bulk RNA sequencing

RNA sequencing of primary human aortic or arterial VSMCs after stimulation with transforming growth factor beta-1 (TGF1) revealed marked IL11 upregulation. In vitro, IL11 stimulation of VSMCs resulted in phenotypic switching by increased ECM production and migration/invasion. Neutralizing IL11 antibody treatment abolished phenotypic switching in VSMCs. IL11 plays an important and non-redundant role in VSMC phenotypic switching. SOURCE: Giuseppe D'Agostino ( - Duke-NUS Medical School

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