miR-34a is a known tumor suppressor that targets cell proliferation and apoptosis genes. In this study, we have shown that miR-34a acts as a safeguard for the inflammatory stem cell niche and reparative regeneration by modulating both the immune and epithelial responses to infection and inflammation. We isolated CD4+ T cells and colon epithelial cells from miR-34a-/- and wildtype mice revealed various changes in gene expression. SOURCE: Ergang Wang (ew152@duke.edu) - Xiling Shen Duke University

Pluto Bioinformatics

GSE123628: RNA-seq of Splenic CD4+ T cells and colon epithelial cells from miR-34a-/- and wildtype mice