Pluto Bioinformatics

GSE45930: TRIM28 silences endogenous retroviruses in neural progenitor cells

Bulk RNA sequencing

Here we show that in neural progenitor cells (NPCs) TRIM28 silences transcription of two groups of endogenous retroviruses (ERVs): IAP1 and MMERVK10C. Derepression of ERVs in Trim28-deficient NPCs was associated with a loss of H3K9me3 and resulted in transcriptional upregulation and reverse transcription. These findings demonstrate a unique dynamic transcriptional regulation of ERVs in NPCs. SOURCE: Adamandia Kapopoulou (adamandia.kapopoulou@epfl.ch) - Trono EPFL