Pluto Bioinformatics

GSE137186: Human bone marrow-derived mesenchymal stromal/stem cells retain their trophic repair and immunoregulatory properties but lose their multipotent differentiation capacity after extensive ageing in vitro

Bulk RNA sequencing

To assess the hierarchical importance of multipotent differentiation compared with trophic/immunoregulatory functions of MSCs, we have undertaken a detailed analysis of how these properties change with in vitro ageing of the cells. Using in vitro differentiation and repair models and integrating transcriptomics and proteomics data, we show that the multipotent differentiation capacity of MSCs falls with increasing passage, whereas trophic repair and immunoregulatory potency are maintained. SOURCE: Kim Clarke University of Liverpool