Pluto Bioinformatics

GSE156963: To determine the differentially expressed genes in cancer associated fibroblasts upon ablation of the glutamatergic synapse protein NetrinG1. [RNA-Seq]

Bulk RNA sequencing

Purpose: To determine the differentially expressed genes in cancer associated fibroblasts upon ablation of the glutamatergic synapse protein NetrinG1.; Methods: Cancer associated fibroblast mRNA profiles were generated from Control and NetrinG1 KO fibroblast lines, with controls done in duplicate and KOs in triplicate.; Results: Comparing the mRNA profiles of CON and NetrinG1 KO CAFs, we observed a reversion of many pro-tumor genes and associated pathways upon ablation of NetrinG1 in CAFs.; Conclusions: Loss of NetrinG1 in CAFs results in normalization of CAF gene signatures. SOURCE: suraj peri (suraj.peri@fccc.edu) - Fox chase cancer center

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