Pluto Bioinformatics

GSE135639: Pro-opiomelanocortin (POMC) neuron translatome signatures underlying obesogenic gestational malprogramming

Bulk RNA sequencing

Maternal unbalanced nutritional habits during embryo development and perinatal stages perturb hypothalamic neuronal programming of the offspring, thus increasing diabesity risk. Here we report that exposure to high-fat diet during gestation and lactation did not interfere with progenys hypothalamic POMC neuron specification, but significantly impaired their spatial distribution and axonal extension to target areas. Importantly, we established POMC neuron-specific translatome signatures accounting for neuronal aberrant development and axonal growth. These anatomical and molecular alterations caused metabolic dysfunction in early-life and adulthood. Our study provides fundamental insights on the molecular mechanisms underlying POMC neuron malprogramming in obesogenic contexts. SOURCE: Jordi Altirriba (jorge.altirriba@unige.ch) - Laboratoire du Métabolisme Centre Médical Universitaire de Genève