Pluto Bioinformatics

GSE87561: Gene expression profile analysis of CD8+ T cells isolated from splenic red and white pulp upon LCMV infection

Bulk RNA sequencing

We performed RNAseq analysis on CD8+ T cells isolated from splenic white and red pulp upon lymphocytic choriomeningitis virus-Arm infection to understand how cell function and fate are determined. Analyses of transcriptional profiles revealed that decisions for gene expression patterns to become a memory cell were established during the early contraction phase by 11 days post infection (dpi) and their expression remained constant throughout the T cell development. This study may have important implication for development of efficacious vaccines. SOURCE: Arash Grakoui Emory University