Pluto Bioinformatics

GSE139091: Hemopexin is a novel tumor suppressor that blocks cancer metastasis by modulating heme:DNA G-quadruplex dynamics to control c-myc expression

Bulk RNA sequencing

Treamtent of PC3 prostate cancer cell line results in enhanced colony growth and c-myc expression. Further, heme promotes tumro growth and metasease in in vivo models of carcinogenesis SOURCE: Mahmoud,Adel,Bassal (mbassal@bidmc.harvard.edu) - Tenen Lab Beth Israel Deaconess Medical Center