Pluto Bioinformatics

GSE57147: DNA-damage induced differentiation of leukemic cells as an anti-cancer barrier

Bulk RNA sequencing

Here we show that the histone methyltransferase MLL4 (Kmt2d) is required for stem cell activity and an aggressive form of acute myeloid leukemia (AML) harboring the MLL-AF9 oncogene. MLL4 exerts its function by regulating transcriptional programs associated with the anti-oxidant response. SOURCE: Robert,Babak,Faryabi (faryabib@mail.nih.gov) - Laboratory of Genome Integrity National Institutes of Health