Pluto Bioinformatics

GSE116390: Single-cell RNA-seq of sorted CD8+ T cells from B16 melanoma tumors

Bulk RNA sequencing

CD8 T cells are the main effectors of the adaptive immune response against intracellular pathogens and cancer. Chronic antigen stimulation and inflammation lead to CD8 T cell differentiation and function that differ from those generated during acute infections. A comprehensive definition of the heterogeneity existing within both tumor-specific and total CD8 tumor-infiltrating T cells remains to be clearly established. To investigate this heterogeneity at the transcriptomic level, we performed paired single-cell RNA and TCR sequencing of >3500 CD8 T cells infiltrating B16 murine melanoma tumors, including cells of known tumor-specificity. SOURCE: Santiago Carmona (sjcarmona@gmail.com) - UNIL