Goal: Comparison of mRNA expression profiles in primary tumors based on activation of different AKT paralogs;	Methods: RNA sequencing performed at the High-Throughput Genomics and Bioinformatics Analysis Core at the University of Utah. Detailed procedures available in methods and DNA processing pipline sections.;	Results: Focus of study compared mRNA expression profiles of BRAFV600E;Cdkn2a-/-;Pten-/- and  BRAFV600E;Cdkn2a-/-;Pten-/-;AKT1E17K cohorts. PCA and unsupervised heirarchical clustering revealed samples clustered together appropriately. Seventeen of eighteen FA factor genes analyzed were upregulated in the AKT1E17K cohort.;	Conclusion: AKT1E17K has a critical role in upregulating a large group of FA factors SOURCE: Sheri Holmen (sheri.holmen@hci.utah.edu) -  University of Utah

Pluto Bioinformatics

GSE122781: RNA sequencing of mutant AKT tumors