Pluto Bioinformatics

GSE129472: Gene expression profiles of Foxp3RFP (WT), Foxp3EGFPiCre (Foxp3-deficient) and Foxp3EGFPiCreRictor/ (Foxp3-deficient and Rictor deficient) Treg cells.

Bulk RNA sequencing

Comparaison of the transcriptomes of WT and Foxp3-deficient regulatory T cells from the spleen of females that carried one mutant Foxp3EGFPiCre allele and a second competent Foxp3 allele (Foxp3RFP) that also directed the expression of the red fluorescent protein (RFP) . We then extended these studies to elucidate transcriptional pathways altered upon Rictor deletion in Treg cells that may contribute to their improved regulatory function by analyzing the transcriptome of Treg cells isolated from Foxp3EGFPiCre/+Rictor/ females. SOURCE: Matteo PellegriniPellegrini Lab UCLA