Pluto Bioinformatics

GSE126957: The regeneration transcriptome of corticospinal neurons

Bulk RNA sequencing

In the present study, we identify transcriptional mechanisms associated with corticospinal regeneration. We took advantage of the ability of NPC grafts to support corticospinal regeneration, together with a genetic mouse model (Glt25d2-GFP-L10a mice, in which a bacterial artificial chromosome (BAC) codes for GFP-tagged polyribosomes in layer 5b cortical neurons) to selectively enrich actively translated mRNA pools from layer Vb cortical projection neurons containing corticospinal neurons (Doyle et al., Cell 2008). SOURCE: Riki Kawaguchi (rkawaguchi@mednet.ucla.edu) - Giovanni Coppola, Informatics Center for Neurogenetics and Neurogenomics (ICNN). University of California Los Angeles