Pluto Bioinformatics

GSE67519: Genome-wide mapping of TEL-AML1 targets in acute leukemia

Bulk RNA sequencing

Around 20-25% of childhood acute lymphoblastic leukemias carry the TEL-AML1 (TA) fusion gene. It is a fusion of two central hematopoietic transcription factors, TEL (ETV6) and AML1 (RUNX1). Despite its prevalence, the exact genomic targets of TA have remained elusive. We evaluated gene loci and enhancers targeted by TA genome-wide in precursor B acute leukemia cells using global nuclear run-on sequencing (GRO-seq). SOURCE: Merja Heinäniemi university of eastern finland