Acetylation of histones by lysine acetyltransferases (KATs) is essential for transcriptional regulation of gene expression. The MYST family of KATs (KAT5-8) includes the oncogenes KAT6A (MOZ) and KAT6B (MORF/QKF). KAT6A has key roles in promoting cell proliferation through transcriptional activation of negative regulators of the Cdkn2a locus, which encode the tumor suppressors INK4A and ARF. To examine the loss of KAT6A function, mouse embryonic fibroblasts (MEFs) were isolated from E13.5 Kat6a+/+ and Kat6a/ embryos and RNA-seq profiling was performed. SOURCE: Alexandra Garnham (garnham.a@wehi.edu.au) -  Walter and Eliza Hall Institute of Medical Research

Pluto Bioinformatics

GSE108242: RNA-seq profiling of mouse embryonic fibroblasts from Kat6a knockout and wildtype mice