PPAR/ has been suggested to be involved in the regulation of the angiogenic switch in tumor progression. However, until now it is not clear to what extent the expression of PPAR/ in tumor endothelium influences tumor progression and metastasis formation. We addressed this question using transgenic mice with an inducible conditional vascular-specific overexpression of PPAR/. Following specific over-expression of PPAR/ in endothelial cells, we induced syngenic tumors. We observed an enhanced tumor growth, a higher vessel density, and enhanced metastasis formation in the tumors of animals with vessel-specific overexpression of PPAR/. In order to identify molecular downstream targets of PPAR/ in the tumor endothelium, we sorted endothelial cells from the tumors and performed RNA sequencing.We show here that PPAR/ activation, regardless of its action on different cancer cell types, leads to a higher tumor vascularization which favors tumor growth and metastasis formation. SOURCE: Kay-Dietrich Wagner (kwagner@unice.fr) -  INSERM

Pluto Bioinformatics

GSE140513: Vascular PPARb/d Promotes Tumor Angiogenesis and Progression