How LTR-signalling drives chronic tissue damage particularly in the lung, which mechanisms regulate this process, and whether LTR-blockade might be of therapeutic value has remained unclear. To study the mechanisms underlying LTR-inhibition, a transcriptional analysis was performed on lung tissue from B6 mice exposed to cigarette smoke for 6 months and treated therapeutically with LTR-Ig from 4 to 6 months compared to mice exposed to cigarette smoke for 6 months and treated with control Ig from 4 to 6 months and filtered air control. Single-cell RNA-Seq identified 24 distinct cell populations across >20,000 cells in lungs with distinct changes occurring upon cigarette smoke exposure and LTR-Ig treatment. SOURCE: Meshal Ansari (meshal.ansari@helmholtz-muenchen.de) -  Helmholtz Zentrum Munich

Pluto Bioinformatics

GSE151674: Analysis of lung transcriptomic changes following inhibition of LTR-signalling in cigarette smoke exposed mice