Pluto Bioinformatics

GSE140468: scRNA sequencing of total CD4+ T cells in spinal cord of EAE mice and SILP of SFB-colonized mice

Bulk RNA sequencing

There are two aims in this study (1) To figure out the pathogenic sub-populations of CD4+ T cells in the spinal cord of EAE model; and (2) by comparing the gene expression profile of pathogenic Th17 cells in EAE model to that of the non-pathogenic Th17 cells induced by SFB in SILP, to identify genes candidates that are potentially selectively essential to pathogenic ones. SOURCE: Dan Littman New York University School of Medicine