Pluto Bioinformatics

GSE134515: Transcriptomic analysis of Sh2d2a knockout regulatory T cells following a time-course of anti-CD3 stimulation

Bulk RNA sequencing

We report that the T cell specific adaptor protein (TSAd, encoded by the Sh2d2a gene) serves as a critical cell intrinsic molecule in CD4+Foxp3+ regulatory T cells to regulate cellular activation responses, mitochondrial translocation of Lymphocyte-specific protein tyrosine kinase (Lck) and immunoregulation following solid organ transplantation SOURCE: Johannes Wedel (johannes.wedel@childrens.harvard.edu) - Boston Children's Hospital