Pluto Bioinformatics

GSE66014: Global Gene Expression analysis of CUTLL1 cell lines after treatment with Perhexiline

Bulk RNA sequencing

We identify perhexiline, a small molecule inhibitor of mitochondrial carnitine palmitoyltransferase-1, as a HES1-signature antagonist drug with robust antileukemic activity against NOTCH1 induced leukemias in vitro and in vivo. SOURCE: Alberto Ambesi-Impiombato Columbia University