Using an established mouse model of chronic exposure, previous work by our group had linked preconception paternal alcohol use to sex-specific patterns of fetal growth restriction and placental dysfunction. The goal of the present study was to investigate the long-term impact chronic preconception paternal alcohol exposure has on offspring growth and metabolic programming. In the male offspring, we observed increases in both the expression of genes within the pro-fibrotic TGF- signaling pathway as well as total levels of cellular hydroxyproline within the liver. Further, we identified suppressed cytokine profiles, which could be linked to the up-regulation of genes in the LiverX/RetinoidX/FarnesoidX Receptor pathways. SOURCE: MICHAEL,C.,GOLDING (mgolding@cvm.tamu.edu) - Golding Lab Texas A&M UNiversity

Pluto Bioinformatics

GSE117559: RNA-sequencing of liver samples derived from offspring sired by males chronically exposed to alcohol prior to conception