Pluto Bioinformatics

GSE144978: Determine in vivo the contribution of distal intestinal segments to calcium homeostasis and bone mineralization

Bulk RNA sequencing

To explore this question, we will use three different male mouse models including VDR KO mice and transgenic mice with hVDR only expressed in the distal intestine (KO/VDR-Tg). All the mice which are C57BL6J background will be raised until 2-3 months old with standard chow diet (n=3 mice per genotype group). Compared to the KO/VDR-Tg mice without any injection, the same type of mice will be administered 1 ng/g bw 1,25(OH)2D3 at 48, 24 and 6 hours prior to termination to determine both early and late effects of 1,25(OH)2D3. SOURCE: Michael,P,VerziVerzi Rutgers, the State University of New Jersey