Pluto Bioinformatics

GSE140389: Effectof high fat diet on phenotype, brain transcriptome and lipidome in Alzheimer's model mice

Bulk RNA sequencing

We examined theeffectof chronic high fat diet (HFD) on amyloid deposition and cognition of 12-months old APP23 mice, and correlated the phenotype to brain transcriptome and lipidome.HFDsignificantly increased amyloid plaques and worsened cognitive performance compared to mice on normal diet (ND). SOURCE: Iliya Lefterov (iliya.lefterov@pitt.edu) - Lefterov/Koldamova University of Pittsburgh